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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Related Experiment Video

Updated: Jan 17, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Advancing Antibody Titer Assessment in ABO-Incompatible Transplantation.

Masayuki Tasaki1, Kazuhide Saito1, Kota Takahashi2

  • 1Division of Urology, Department of Regenerative & Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.

Antibodies (Basel, Switzerland)
|September 22, 2025
PubMed
Summary
This summary is machine-generated.

Accurate anti-ABO antibody measurement is crucial for ABO-incompatible transplantation risk. Novel assays targeting endothelial cells offer more precise evaluation than traditional red blood cell methods.

Keywords:
ABO-incompatible transplantationCD31anti-ABO antibody titerglycan microarrayhemagglutination-based methods

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Area of Science:

  • Transplantation immunology
  • Immunoserology

Background:

  • Accurate anti-ABO antibody evaluation is critical for risk stratification in ABO-incompatible (ABOi) transplantation.
  • Traditional hemagglutination assays have limitations in precision and clinical relevance.

Purpose of the Study:

  • To review recent advancements in anti-ABO antibody measurement techniques for ABOi organ transplantation.
  • To highlight novel assays that assess antibodies against endothelial cell-expressed ABO antigens.

Main Methods:

  • A narrative review of studies from PubMed, Scopus, and Google Scholar.
  • Focus on recent evaluations of anti-ABO antibody measurement techniques in ABOi transplantation.

Main Results:

  • Conventional methods (tube, column agglutination, flow cytometry, ELISA) show inter-assay variability and may not reflect clinical context.
  • Novel assays like glycan and CD31-based microarrays assess antibodies against endothelial ABO antigens.
  • These new methods offer potential for more accurate and standardized assessments.

Conclusions:

  • Objective evaluation of anti-ABO antibodies on vascular endothelial cells can improve risk assessment in ABOi transplantation.
  • Standardized assays facilitate more reliable comparisons between institutions.
  • Advancements in antibody measurement are key to optimizing ABOi transplant outcomes.