Global Genomic Surveillance: On-The-Ground Responses.

Area of Science:

• Virology
• Epidemiology
• Public Health

Background:

• Genomic surveillance is essential for managing dengue virus (DENV) outbreaks.
• It aids in detecting viral strains, monitoring transmission, and assessing evolutionary changes impacting control.

Purpose of the Study:

• To examine the role of genomic surveillance in the dengue crisis.
• To compare regional approaches and identify implementation challenges.
• To propose strategies for enhancing genomic surveillance.

Main Methods:

• Comparative analysis of regional genomic surveillance strategies.
• Review of challenges in implementation, including infrastructure and data sharing.
• Exploration of future directions and technological integration.

Main Results:

• Genomic surveillance significantly contributes to outbreak detection, strain characterization, and vaccine efficacy assessment.
• Disparities exist in genomic surveillance infrastructure and capacity globally.
• Logistical and accessibility issues hinder widespread implementation, especially in resource-limited settings.

Conclusions:

• Strengthening international collaboration and capacity-building is key.
• Integrating real-time sequencing with modeling can improve public health decision-making.
• A coordinated, sustainable approach to genomic data is needed for better arbovirus preparedness.