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Idiopathic Retinitis Vasculitis Aneurysms and Neuroretinitis (IRVAN) Treated with Adalimumab: A case report

L Van Winckel¹, I Casteels², P P Schauwvlieghe²

¹Faculty of Medicine, KU Leuven, Leuven, Belgium.

Retinal Cases & Brief Reports

|September 22, 2025

Abstract

Purpose:

To report a case of idiopathic retinal vasculitis, aneurysm, and neuroretinitis (IRVAN) syndrome with good response to treatment with Adalimumab in addition to panretinal photocoagulation (PRP).

Methods:

Case report.

Results:

We describe a case of IRVAN in an adolescent who had been initially treated with PRP and intravitreal injections of Ranibizumab in both eyes. Due to persistent retinal ischemia and vasculitis, treatment with subcutaneous injections of Adalimumab was initiated. After 1.5 years of follow-up, there was resolution of retinal vasculitis, and reversal of some retinal capillary non-perfusion with substantial regression of retinal ischemia.

Conclusion:

Treatment with Adalimumab may be useful in controlling disease activity in patients with IRVAN syndrome.

Keywords:

Adalimumab Aneurysmal dilatation IRVAN Neuroretinitis Vasculitis

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Keywords:

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