Recent Advances in Diagnostic Strategies and Nanotechnology-Based Therapies for Ovarian Cancer Treatment

Arti Vashist1, Pandiaraj Manickam2,3, Gopi Karuppaiah2

  • 1Department of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States.

ACS Applied Bio Materials
|September 22, 2025
PubMed

Insights

Nanotechnology offers new hope for ovarian cancer treatment by improving drug delivery and diagnostics. This review explores nanoparticle advancements, nanoimmunotherapy, and AI integration for better ovarian cancer outcomes.

Area of Science:

  • Oncology
  • Nanotechnology
  • Immunology

Background:

  • Ovarian cancer is a leading cause of gynecologic cancer deaths, often diagnosed late with high recurrence rates.
  • Current treatments face challenges due to advanced diagnosis and therapy resistance.
  • There is a critical need for novel and effective ovarian cancer therapeutics.

Purpose of the Study:

  • To review recent advancements in nanoparticle-based drug delivery for ovarian cancer.
  • To explore the role of nanotechnology in ovarian cancer diagnostics and treatment, including nanoimmunotherapy.
  • To discuss the integration of innate immune responses, AI, and nanocarriers in ovarian cancer management.

Main Methods:

  • Comprehensive literature review of nanotechnology applications in ovarian cancer.
  • Analysis of recent progress in nanoparticle formulations, nanoimmunotherapy, and diagnostic tools.
  • Examination of the interplay between innate immunity and nanocarrier-based interventions.

Main Results:

  • Nanoparticle drug-delivery systems show significant promise for ovarian cancer treatment and diagnostics.
  • Nanoimmunotherapy and advanced diagnostic tools are emerging as key areas of progress.
  • Artificial intelligence is poised to enhance clinical diagnosis protocols for ovarian cancer.

Conclusions:

  • Nanotechnology offers a promising interdisciplinary approach to combat ovarian cancer.
  • Integrating innate immune responses with nanocarrier strategies can improve therapeutic efficacy.
  • Future research should focus on overcoming challenges and optimizing nanocarrier applications for ovarian cancer.