MULTIMODAL IMAGING OF BENIGN LOBULAR INNER NUCLEAR LAYER PROLIFERATIONS.

Area of Science:

• Ophthalmology
• Retinal Imaging
• Pathology

Background:

• Benign lobular inner nuclear layer proliferations (BLIP) are exceptionally rare retinal tumors.
• Congenital hypertrophy of the retinal pigment epithelium (CHRPE) lesions are more common but can present in various forms.

Purpose of the Study:

• To document the clinical presentation and multimodal imaging characteristics of a patient with bilateral BLIP.
• To investigate the association between BLIP and grouped CHRPE lesions.

Main Methods:

• A 10-year-old male patient underwent comprehensive multimodal imaging.
• Imaging modalities included fundus photography, autofluorescence, optical coherence tomography (OCT), and OCT angiography (OCTA).

Main Results:

• Bilateral intraretinal lesions consistent with BLIP were identified in the posterior pole and midperiphery.
• Extensive bilateral grouped CHRPE lesions were also observed.
• OCT revealed homogeneous hyperreflective foci in the inner nuclear layer (INL) without intrinsic vasculature on OCTA, showing interocular and intraocular variability.

Conclusions:

• The findings confirm the diagnosis of BLIP associated with CHRPE.
• This case contributes to the limited literature on BLIP, emphasizing its rarity and the utility of multimodal imaging for diagnosis.