Related Experiment Video
Updated: Jan 17, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
Published on: July 11, 2025
MAPPING AFFECTIVE PROFILES IN DEPRESSION, BURNOUT, NORMAL SADNESS, AND EUTHYMIC STATE: A SELF-REPORT SCREENING TOOL
Danil Trofimov1, Maria Zapriy2, Anna Khomenko3
1Department of Digital Data Processing Technologies, MIREA - Russian Technological University, Moscow, Russia.
This study developed a sensitive self-report screening tool using machine learning to accurately differentiate mental health states, from preclinical to severe conditions, achieving 100% accuracy in classifying depression, burnout, and sadness.
Area of Science:
- Psychiatry and Mental Health
- Computational Psychology
- Health Informatics
Background:
- Modern society faces challenges impacting mental health, increasing affective disorders.
- A need exists for sensitive tools to differentiate preclinical and clinical affective states.
- Affective spectrum disorders require accurate and accessible screening methods.
Purpose of the Study:
- To develop a sensitive self-questionnaire for differentiating affective states.
- To utilize machine learning (ML) for accurate classification of mental health conditions.
- To identify key affective symptom domains for improved diagnostic accuracy.
Main Methods:
- A two-stage online survey was developed and administered to university staff and students.
- Machine learning methods were applied for data analysis and respondent classification.
- A final 34-question survey was refined based on statistical analysis and classification tasks.
Main Results:
- Significant differences were found between euthymia, normal sadness, emotional burnout, and depression groups (p < .001).
- The ML-based tool achieved 100% accuracy in classifying affective states in the final iteration.
- The final distribution showed euthymia (38.8%), normal sadness (27.3%), emotional burnout (25.2%), and depression (8.7%).
Conclusions:
- The developed self-report tool accurately classifies the affective spectrum using ML.
- Integration of clinical assessments with ML algorithms enhances diagnostic accuracy and reduces costs.
- Further clinical research is needed to refine the tool's sensitive symptom domains.
Related Concept Videos
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Traits, Mood, and Subjective Wellbeing
Neuroticism and...
The Influence of Affect on Cognition
Depression: Overview
Self-Report Tests of Personality

