Related Experiment Video

Updated: Jan 17, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.4K

STIFFNESS OF ARTERIES AND LEFT ATRIUM AS PREDICTORS FOR COGNITIVE IMPAIRMENT IN CARDIOLOGY PATIENTS

Olga Germanova1, Yulia Reshetnikova1, Ksenia Ermolayeva1

  • 1International Centre for Education and Research in Cardiovascular Pathology and Cardiovisualization, Samara State Medical University, Samara, Russia.

Psychiatria Danubina
|September 22, 2025
PubMed

Insights

Patients with frequent extrasystoles and atrial fibrillation experience cognitive decline, particularly those with atrial fibrillation. Arterial stiffness and left atrial changes predict this impairment.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Heart arrhythmias, including frequent extrasystoles (ES) and paroxysmal atrial fibrillation (AF), are prevalent conditions.
  • Cognitive function can be affected by cardiovascular health, but the specific relationship with advanced cardiac imaging parameters in arrhythmias requires further investigation.

Purpose of the Study:

  • To investigate the association between cognitive function and volumetric sphygmography and speckle tracking echocardiography data in patients with heart arrhythmias.
  • To compare cognitive function and cardiac parameters in patients with frequent ES, paroxysmal AF, and a control group.

Main Methods:

  • A monocentric cohort study involving 33 patients divided into three groups: frequent ES (n=12), paroxysmal AF (n=14), and controls (n=7).
  • Data collection included lipidograms, 24-hour ECG monitoring, transthoracic echocardiography (TTE), volumetric sphygmography, and the Montreal Cognitive Assessment (MoCA) test for cognitive evaluation.

Main Results:

  • Patients with frequent ES and paroxysmal AF showed decreased cognitive function (MoCA scores), most notably in the paroxysmal AF group.
  • Significant differences were observed in left atrial (LA) volume and MoCA scores between the arrhythmia groups and the control group.
  • Reduced global longitudinal strain (GLS) in the left ventricle was noted in the paroxysmal AF group compared to the frequent ES group, indicating impaired systolic function.

Conclusions:

  • Cognitive impairment develops in patients with frequent ES and paroxysmal AF, with paroxysmal AF presenting a more significant impact.
  • Increased arterial stiffness parameters (R-CAVI, L-CAVI) and structural LA changes (increased LA volume, decreased LA strain) are identified as significant predictors of cognitive impairment.
  • Paroxysmal AF patients exhibited the most pronounced differences across key cardiovascular and cognitive parameters compared to the control group.
Abstract

Keywords:
CAVIMoCAcognitive functionheart arrhythmiasleft atrial strain

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

11.1K
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.4K

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
474
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
418
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
461
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.3K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
218
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
375