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Epidemiology and Risk Factors for Constrictive Pericarditis in a Statewide Australian Cohort of Patients With

Timothy N Kwan1, Gemma Kwan1, David Brieger1

  • 1Department of Cardiology, Concord General Repatriation Hospital, The University of Sydney, Concord, New South Wales, Australia.

The Canadian Journal of Cardiology
|September 22, 2025
PubMed

Insights

Constrictive pericarditis is rare, but risk factors like tuberculosis, malignancy, liver disease, and heart failure increase its likelihood. Long-term monitoring is crucial for patients with pericardial disease.

Area of Science:

  • Cardiology
  • Epidemiology

Background:

  • Constrictive pericarditis is a serious complication of pericardial disease.
  • Limited longitudinal studies exist on its risk factors.
  • This study evaluates epidemiology and predictors in a large cohort.

Purpose of the Study:

  • To assess the epidemiology and identify predictors of constrictive pericarditis.
  • To analyze risk factors in a large, population-based cohort.

Main Methods:

  • Retrospective cohort study (2004-2021) using the NSW Admitted Patient Data Collection database.
  • Multivariable logistic regression for index admission risk factors.
  • Time-dependent Cox regression and Fine-Gray method for follow-up risk factors.

Main Results:

  • 1.7% of 45,445 patients developed constrictive pericarditis.
  • Index presentation risk factors: malignancy, tuberculosis, liver disease, heart failure.
  • Follow-up risk factors: heart failure hospitalization, recurrent pericardial disease, pericardiocentesis.

Conclusions:

  • Constrictive pericarditis is rare but associated with specific conditions.
  • Tuberculosis, malignancy, liver disease, heart failure, and procedures increase risk.
  • Long-term vigilance is essential for at-risk populations.
Abstract

Keywords:
constrictive pericarditispericardial diseasepericardiocentesispericarditis

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