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Associations of Serum n-6 Polyunsaturated Fatty Acid Concentrations with Heart Rate-Corrected QT and JT Intervals in
Haleh Esmaili1, Behnam Tajik2, Tomi-Pekka Tuomainen1
1Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Background:
Although n-6 (ω-6) polyunsaturated fatty acids (PUFAs), particularly the main n-6 PUFA linoleic acid (LA), have been shown to be inversely related to cardiovascular disease (CVD) risk, their associations with ventricular repolarization, a marker of ventricular arrhythmias, remain unclear.
Objectives:
This study examined the relationships between serum n-6 PUFA concentrations and heart rate-corrected QT (QTc) and JT (JTc) intervals.
Methods:
This cross-sectional study included 1420 Finnish males (aged 42-60 y) free of CVD from the Kuopio Ischaemic Heart Disease Risk Factor Study. Fasting serum n-6 PUFA concentrations were determined by gas chromatography, and electrocardiographic intervals were automatically derived. QTc and JTc intervals were calculated using Bazett's formula. Associations were analyzed using multivariable-adjusted analysis of covariance.
Results:
Higher serum total n-6 PUFA concentrations were associated with shorter QTc and JTc intervals [QTc, extreme-quartile difference: -3.36 ms; 95% confidence interval (CI): -6.69, -0.41; P-trend = 0.02; JTc, extreme-quartile difference: -3.38 ms; 95% CI: -6.79, -0.27; P-trend = 0.03]. Similar inverse associations were found for serum LA (QTc: -4.64 ms; 95% CI: -8.00, -1.27; P-trend = 0.009; JTc: -3.99 ms; 95% CI: -7.44, -0.54; P-trend = 0.02). The other n-6 PUFAs-γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid-showed no significant associations.
Conclusions:
Higher serum total n-6 PUFA and LA concentrations are associated with shorter QTc and JTc intervals, suggesting a potential protective effect on ventricular arrhythmias.
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