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Updated: Jan 17, 2026
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Inclusion of emergency department attendance on classification of Clostridioides difficile infection-onset status: a
Antoine Salzmann1, Akaninyene Otu2, Olisaeloka Nsonwu1
1Antimicrobial Resistance and Healthcare Associated Infections Division, Epidemic and Emerging Infections Directorate, UK Health Security Agency, London, UK.
Abstract:
Algorithms used to classify Clostridioides difficile infection (CDI) as hospital- or community-onset have commonly relied on the duration between patient hospital admission and specimen date for classification. This, however, fails to account for patient stays in emergency departments prior to inpatient hospital admission. The UK Health Security Agency addresses this concern in a revised definition, implemented as of April 2024. In England, from April 2020 to March 2024, conventional definitions led to 6.7% of hospital-onset CDI cases being misclassified as community-onset. These findings reinforce the rationale for updating England's CDI-onset definition, ensuring more accurate and standardized CDI categorization.
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