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Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Barrett Esophagus-I: Introduction01:21

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Research Communication: Reflux Disease May Constitute a Risk Factor for Colonic Neoplasia.

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  • 1Section of Gastroenterology, Portland VA Medical Center, Oregon, Portland, USA.

Alimentary Pharmacology & Therapeutics
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Long-term use of acid-reducing medications may increase risks for colon polyps and colorectal cancer. Reflux disease, including erosive esophagitis and Barrett

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Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Long-term inhibition of gastric acid secretion is a common medical practice.
  • Potential associations between acid suppression and gastrointestinal neoplasia require investigation.
  • Reflux disease encompasses conditions like non-erosive reflux disease (NERD), erosive esophagitis (EE), Barrett's esophagus (BE), and eosinophilic esophagitis (EoE).

Purpose of the Study:

  • To investigate the potential association between long-term gastric acid secretion inhibition and the incidence of colon polyps (CP) and colorectal cancer (CRC).
  • To examine the concurrence of CP or CRC with specific reflux disease diagnoses (NERD, EE, BE, EoE) in a large patient cohort.

Main Methods:

  • A case-control study design was employed.
  • Utilized the inpatient data file from the Centers for Medicare and Medicaid Services (CMS).
  • Analyzed data from 6,462,321 individual patients.

Main Results:

  • Colon polyps (CP) and colorectal cancer (CRC) showed significant associations with erosive esophagitis (EE), non-erosive reflux disease (NERD), and Barrett's esophagus (BE).
  • The study identified a statistically significant link between specific types of reflux disease and colonic neoplasia.

Conclusions:

  • Reflux disease is associated with an increased risk of developing colonic neoplasia, including colon polyps and colorectal cancer.
  • Findings suggest a potential link between conditions treated by long-term acid suppression and the development of colon neoplasia.