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Cell death mechanisms during Mycobacterium tuberculosis infection: A perspective from a host-pathogen interface
Prachi Nangpal1, Nupur Angrish1, Garima Khare1
1Department of Biochemistry, University of Delhi South Campus, New Delhi, India.
Progress in Molecular Biology and Translational Science
|September 22, 2025
Summary
Mycobacterium tuberculosis (Mtb) evades host immunity by inhibiting cell death pathways. Understanding these host-pathogen interactions is key to developing new host-directed therapies for tuberculosis.
Area of Science:
- Immunology
- Microbiology
- Cell Biology
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a significant global health threat.
- Mtb is an intracellular pathogen that employs sophisticated mechanisms to evade host immune responses.
- Cell death pathways, including apoptosis, pyroptosis, necroptosis, and autophagy, are crucial for controlling intracellular pathogens like Mtb.
Purpose of the Study:
- To explore the role of various cell death modalities in anti-TB immunity.
- To investigate how Mtb inhibits host cell death pathways as a virulence strategy.
- To highlight the potential of host-directed therapies (HDTs) for TB treatment.
Main Methods:
- Review of existing literature on Mtb-host interactions and cell death pathways.
- Analysis of Mtb's mechanisms for subverting host immunity.
- Exploration of signaling cascades involved in cell death and Mtb infection.
Main Results:
- Mtb actively inhibits host cell death processes to ensure its survival and replication.
- Dysregulation of cell death pathways by Mtb contributes to persistent infection and pathogenesis.
- Targeting host cell death pathways offers a promising avenue for novel therapeutic strategies.
Conclusions:
- Understanding Mtb's manipulation of host cell death is crucial for advancing TB research.
- Host-directed therapies modulating cell death offer a complementary approach to traditional anti-TB drugs.
- Further research into host-pathogen interactions at the cellular level will facilitate the design of effective HDTs for tuberculosis.
Keywords:
ApoptosisAutophagyBacterial infectionCell death mechanismsFerroptosisHost directed therapiesMycobacterium tuberculosisNecroptosisPyroptosisMore Related Videos
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