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Related Experiment Video

Updated: Jan 17, 2026

Viral Tracing of Genetically Defined Neural Circuitry

Viral Tracing of Genetically Defined Neural Circuitry

Published on: October 17, 2012

Scar wars: the viral menace.

Sara Kass-Gergi^1,2,3, Nicolas P Holcomb^4,2,3, Michael M Maiden^5,2,3

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States.

American Journal of Physiology. Lung Cellular and Molecular Physiology

|September 22, 2025

Summary

Viral infections like COVID-19 can lead to pulmonary fibrosis (PF), a condition causing irreversible lung damage. This review explores how respiratory viruses trigger mechanisms leading to chronic fibrotic lung disease in survivors.

Keywords:

COVID immune-mesenchymal cross talk interstitial lung disease post-viral immune dysregulation pulmonary fibrosis

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Last Updated: Jan 17, 2026

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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

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Published on: September 27, 2014

Area of Science:

Pulmonology
Virology
Pathology

Background:

Pulmonary fibrosis (PF) is lung scarring from infections, causing irreversible damage.
PF is increasingly observed post-viral infections, especially in severe cases like ARDS.
The COVID-19 pandemic highlighted chronic fibrotic changes in survivors of severe viral pneumonia.

Purpose of the Study:

To review clinical evidence linking viral infections to pulmonary fibrosis.
To investigate the mechanisms driving fibrosis after viral infections (COVID-19, influenza, etc.).
To understand how acute viral injury progresses to chronic fibrotic lung disease.

Main Methods:

Literature review of clinical studies and mechanistic research.
Analysis of pathways involving cellular injury and immune responses.
Examination of aberrant repair mechanisms post-viral infection.

Main Results:

Viral infections, including COVID-19 and influenza, are linked to pulmonary fibrosis onset.
Mechanisms involve cellular damage, immune system dysregulation, and abnormal tissue repair.
These pathways can convert acute viral lung injury into chronic fibrotic disease.

Conclusions:

Viral infections represent a significant risk factor for developing pulmonary fibrosis.
Understanding these mechanisms is crucial for managing post-viral lung disease.
Further research into therapeutic targets for preventing or treating viral-induced PF is warranted.