Radiomics in preclinical imaging research: methods, challenges and opportunities

Radiomics-based analyses are increasingly being applied to clinical studies. Radiomic features can be correlated with markers of disease severity or treatment success to improve early detection of disease and develop predictive models for therapeutic response. While radiomics has similar potential in preclinical research, its use in this context entails unique challenges. This paper provides an overview of the current state of radiomics in preclinical imaging, methodologies, challenges and future prospects.