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Related Experiment Video

Updated: Jan 17, 2026

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The SMART Model: A Simplified Model for Assessing the Resilience of Therapeutic Program Financial Viability.

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Summary

The SMART Model assesses therapeutic program financial viability for biopharmaceutical interventions. It identifies late-preclinical development and funding delays as key cost drivers, improving defense planning.

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Area of Science:

  • Biopharmaceutical Development
  • Health Security
  • Economic Modeling

Background:

  • U.S. Department of Defense (DoD) faces budget constraints for biopharmaceutical interventions.
  • Successful development increasingly requires private investment, necessitating market viability assessments.
  • Lack of empirical models hinders evaluation of private sector involvement in therapeutic programs.

Purpose of the Study:

  • To introduce the Simplified Model for Assessing the Resilience of Therapeutic Program Financial Viability (SMART Model).
  • To provide an empirical tool for assessing market viability and private sector engagement in DoD biopharmaceutical programs.
  • To identify key factors influencing financial sustainability in therapeutic development.

Main Methods:

  • Developed the SMART Model based on drug development timelines, attrition rates, and costs.
  • Incorporated phase-specific probabilities of technical success, durations, and cost estimates.
  • Utilized projected market penetration and net present value calculations for financial analysis.

Main Results:

  • The model replicates known drug development productivity challenges.
  • Late-preclinical development is a major cost contributor for biologic drugs.
  • Reducing funding and decision-making delays significantly enhances financial viability.

Conclusions:

  • The SMART Model aids defense planners in optimizing resource allocation for financial sustainability.
  • Focusing on reducing development and funding delays improves program financial viability.
  • The model supports resource prioritization for biopharmaceutical interventions with potential private sector cost-sharing.