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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Effect of Kidney Transplant Type on Coronary Endothelial Function in Individuals with Chronic Kidney Disease

Göksel Guz1, Rasim Onur Karaoğlu2, Sezen Kumaş Solak2

  • 1Department of Cardiology, Medicana International Hospital, İstanbul, Turkey.

Annals of Transplantation
|September 23, 2025
PubMed

Insights

Kidney transplantation improves coronary endothelial function and cardiac performance for both living donor (LDT) and cadaver donor (CDT) recipients. However, severe baseline impairment is more frequent in cadaveric recipients.

Area of Science:

  • Cardiology
  • Nephrology
  • Transplantation Science

Background:

  • Chronic kidney disease (CKD) patients face high cardiovascular risk due to endothelial dysfunction (ED).
  • Kidney transplantation is known to improve cardiovascular health.
  • The impact of transplant type (living donor vs. cadaver donor) on coronary endothelial function is not well understood.

Purpose of the Study:

  • To investigate the differential effects of living donor transplantation (LDT) versus cadaver donor transplantation (CDT) on coronary endothelial function.
  • To assess changes in cardiac performance post-kidney transplantation.

Main Methods:

  • Prospective observational study involving 75 kidney transplant recipients (50 LDT, 25 CDT) and 25 healthy controls (HC).
  • Coronary Flow Velocity Reserve (CFVR) measured at baseline (CFVR-1) and 6 months post-transplant (CFVR-2).
  • Assessed Left Ventricular Ejection Fraction (LV-EF), diameters, and NT-proBNP.

Main Results:

  • All transplant recipients showed improved CFVR post-transplantation compared to baseline (p<0.05).
  • No significant difference in CFVR improvement between LDT and CDT groups.
  • Similar improvements in LV-EF (≥10% increase in 36% of patients) observed in both transplant groups.

Conclusions:

  • Kidney transplantation enhances coronary endothelial function and cardiac performance irrespective of donor type.
  • Cadaver donor recipients exhibited a higher prevalence of severe baseline CFVR impairment.

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