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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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A Hydrogel with Low-Temperature Photothermal Therapy and ROS Scavenging Capability for Healing Infected Diabetic

Xin Liu1, Shaopeng Liu1, Bo Ma1

  • 1Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.

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|September 23, 2025
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Summary

This study presents a novel hydrogel for low-temperature photothermal therapy (PTT) to treat diabetic wounds. The nanocomposite hydrogel effectively kills bacteria, reduces inflammation, and accelerates healing with minimal damage to normal tissues.

Keywords:
antibacterial propertydiabetic wound infectionnanocomposite hydrogelphotothermal therapy

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing

Background:

  • Diabetic wound infections pose a significant clinical challenge.
  • Photothermal therapy (PTT) for antimicrobial treatment risks normal tissue damage due to high temperatures.
  • Developing safe and effective PTT strategies for diabetic wounds is crucial.

Purpose of the Study:

  • To fabricate a novel photothermal nanocomposite hydrogel for low-temperature PTT antimicrobial therapy in diabetic wounds.
  • To investigate the synergistic effects of mesoporous polydopamine, Zeolitic Imidazolate Framework-8, and berberine for enhanced antibacterial activity and wound healing.
  • To evaluate the biocompatibility and therapeutic efficacy of the developed hydrogel in a wound healing model.

Main Methods:

  • Fabrication of MPDA@ZIF-8/BBR core-shell nanoparticles.
  • Incorporation of nanoparticles into a carboxymethyl chitosan/oxidized hyaluronic acid hydrogel via Schiff base chemistry.
  • Evaluation of low-temperature PTT antimicrobial activity, ROS scavenging, and drug release kinetics.
  • Assessment of biocompatibility, anti-inflammatory effects, and wound healing acceleration in vivo.

Main Results:

  • The Gel-MPDA@ZIF-8/BBR hydrogel demonstrated controlled degradation in acidic environments, releasing BBR and Zn²⁺.
  • Low-temperature PTT combined with released BBR effectively inhibited bacterial growth and disintegrated biofilms.
  • The hydrogel exhibited good biocompatibility, reduced inflammation, and significantly promoted diabetic wound healing.

Conclusions:

  • The developed photothermal nanocomposite hydrogel offers a promising low-temperature PTT strategy for treating diabetic-infected chronic wounds.
  • The synergistic action of BBR and mild PTT enhances antibacterial efficacy and promotes wound repair.
  • This approach minimizes damage to surrounding healthy tissues, addressing a key challenge in PTT.