Granular Cell Tumor: A Rare Entity Occurring at an Uncommon Site

Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon clinical entity derived from Schwann cells. Most are found in the oral cavity, especially the tongue. However, in this case, a rare clinical presentation occurred on the vulva of a young female patient, who presented with a progressively enlarged solitary nodule on her left labia majora. Histological examination showed a nonencapsulated tumor in the dermis, composed of large cells with abundant granular cytoplasm. Immunohistochemical staining revealed strong expression of S100 by tumor cells. Based on histopathological results, the vulvar tumor has been completely resected under local anesthesia with clear surgical margins of 0.5 cm. The patient has shown no tumor recurrence after six months following the surgery. In short, we think that GCT should be considered as one of the differential diagnosis of a solitary genital tumor at young ages.