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A Case of Marburg Variant Multiple Sclerosis Treated With Rituximab
Melanie Khamlong1, Aishwarya Saripalli1, Noah Yan2
1Internal Medicine, University of California, Los Angeles (UCLA) - Kern Medical, Bakersfield, USA.
Abstract:
Marburg variant is a rare, monophasic form of multiple sclerosis (MS) characterized by an aggressive clinical course. Diagnosis is confirmed with brain MRI demonstrating multiple focal T2-hyperintense lesions and with histopathology. While there is no established standard of care, high-dose corticosteroids followed by immunosuppressive therapies have commonly been used. Rituximab has been reported in the treatment of two previously described cases. We report a case of a 59-year-old woman diagnosed with Marburg variant MS who was successfully treated with rituximab.
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