From Clinical Suspicion to Therapeutic Resolution: A Case of Melkersson-Rosenthal Syndrome

Melkersson-Rosenthal syndrome (MRS) is a rare, chronic condition characterized by orofacial edema, facial paralysis, and fissured tongue. Its etiology remains unclear, although genetic, immunological, and infectious factors have been proposed in its pathogenesis. Various treatment modalities have been suggested, including corticosteroids, antibiotics, immunosuppressants, and, in severe cases, surgical intervention. Early identification is essential to improve prognosis and prevent complications. We report the case of a 33-year-old woman presenting with progressive and persistent oral edema accompanied by a fissured tongue. Histopathological examination confirmed granulomatous cheilitis, leading to the diagnosis of MRS. Treatment with intralesional triamcinolone acetonide and doxycycline was initiated, resulting in an excellent clinical response.