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Updated: Jan 17, 2026

Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
Dopasomes: dopamine-mediated cross-linked lipid vesicles
Keita Yamana1, Kouki Fujihara1, Miu Maeda1
1Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, 1-4-1 Kagamiyama, Higashi-Hiroshima City, 739-8527, Japan.
Abstract:
Liposomes offer significant advantages for drug delivery but are limited by poor stability, which hinders product development and therapeutic efficacy. In biological environments containing surfactant-like components such as serum proteins and bile salts, liposomes are susceptible to destabilization. In this study, we designed and synthesized dopamine-containing, self-polymerizing lipids that self-assemble into liposomal structures, termed as "dopasomes." Dopasomes retained their structural integrity even in the presence of Triton X-100 and enabled efficient intracellular delivery of doxorubicin hydrochloride.
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