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Updated: Jan 17, 2026

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
Published on: May 23, 2025
A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of
Yiran Wang1,2, Mingwan Su3, Lei Li3
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. limin@ihep.ac.cn.
Abstract:
This study created a sensitive Raman ammonia sensor using 2D Cu-TCPP nanosheets for noninvasive H. pylori detection. Leveraging multiple ammonia-binding sites and Au nanoparticle signal enhancement, it achieved a 1 ppm detection limit. Testing patients' breath, it identified H. pylori via ammonia levels, showing clear I997/I1030 ratio shifts post-urea intake, offering a promising noninvasive diagnostic tool.
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