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Correction: Lee et al. Establishment and Characterization of Three Human Ocular Adnexal Sebaceous Carcinoma Cell

Su-Chan Lee1, Cornelia Peterson2, Kaixuan Wang3

  • 1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

International Journal of Molecular Sciences
|September 23, 2025
PubMed

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A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...