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Articles linked to this work by shared authors, journal, and citation graph.

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Updated: Jan 17, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Vascular Closure Device Following Pulsed Field Ablation for Atrial Fibrillation: A Randomized Controlled Trial.

Alexander Dashwood1, Francis J Ha1,2, Stewart Healy1

  • 1Victorian Heart Hospital, Melbourne, Australia.

Pacing and Clinical Electrophysiology : PACE
|September 23, 2025
PubMed
Summary

Vascular closure devices (VCDs) with Prostyle significantly reduced ambulation time and minor bleeding after pulsed field ablation (PFA) for atrial fibrillation (AF). This improves patient recovery and safety following the procedure.

Keywords:
Perclose Prostyle vascular closure deviceatrial fibrillationpulsed field ablationvascular complications

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Surgery

Background:

  • Atrial fibrillation (AF) ablation frequently uses large-diameter catheters, complicating post-procedure hemostasis and patient discharge.
  • The efficacy of Perclose Prostyle vascular closure device (VCD) for improving ambulation time and reducing vascular access complications in patients undergoing pulsed field ablation (PFA) remains unclear.

Purpose of the Study:

  • To evaluate the impact of the Perclose Prostyle VCD compared to figure-of-eight sutures (FO8) on time to ambulation.
  • To assess vascular access complications, including bleeding, in patients undergoing PFA for AF.

Main Methods:

  • A single-center, open-label, randomized controlled trial comparing Prostyle VCD to FO8 closure in patients undergoing PFA for AF with 16.8F sheaths.
  • The primary endpoint was time to ambulation; secondary endpoints included peri-procedural adverse events. Ultrasound guidance was used for all procedures.
  • Sixty patients were randomized (30 per group), with follow-up up to two weeks.

Main Results:

  • Time to ambulation was significantly shorter in the VCD group (215 ± 113 min) versus the FO8 group (338 ± 71 min; p < 0.001).
  • No major peri-procedural adverse events occurred in either group. Minor bleeding was significantly reduced with VCD (0%) compared to FO8 (27%; p = 0.005).
  • Manual compression rates were numerically lower in the VCD group (10%) compared to FO8 (33%; p = 0.057).

Conclusions:

  • Perclose Prostyle VCD significantly reduces time to ambulation post-PFA for AF.
  • VCD use also leads to a significant reduction in minor bleeding complications compared to standard figure-of-eight suture closure.