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Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
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Antihypertensive Medication as a Risk Factor For Basal Cell Carcinoma: A Nationwide Registry-based Case-control Study
Johan Kappelin1, Ingela Ahnlide2, Gustav B Christensen3
1Lund University Skin Cancer Research Group, Department of Clinical Sciences Lund, Dermatology, Lund University, Sweden; Department of Dermatology, Skåne University Hospital, Landskrona, Sweden. johan.kappelin@med.lu.se.
Acta Dermato-Venereologica
|September 23, 2025
Summary
Commonly prescribed blood pressure drugs like thiazides (in combination), ARBs, CCBs, and beta-blockers are linked to higher basal cell carcinoma (BCC) risk. Single-agent thiazide use showed no increased risk.
Area of Science:
- Dermatology
- Pharmacology
- Epidemiology
Background:
- Hydrochlorothiazide is linked to squamous cell carcinoma but its association with basal cell carcinoma (BCC) is debated.
- Antihypertensive medications are widely prescribed, necessitating investigation into their potential BCC risks.
Purpose of the Study:
- To investigate the association between commonly prescribed antihypertensive medications and the risk of developing basal cell carcinoma (BCC).
Main Methods:
- A nationwide, registry-based, case-control study in Sweden (2007-2017).
- Included 133,539 BCC cases and 257,849 matched controls.
- Analyzed data on antihypertensive prescriptions, comorbidities, and socioeconomic factors.
Main Results:
- Thiazide-containing combination treatments (OR 1.09), angiotensin II receptor blockers (OR 1.09), calcium channel blockers (OR 1.09), and beta-blockers (OR 1.07) were associated with increased BCC risk.
- Single-agent thiazide treatment did not show an increased BCC risk.
- Combination thiazide therapy increased BCC risk, suggesting further study of adjunctive substances.
Conclusions:
- Several common antihypertensives are significantly associated with an increased risk of basal cell carcinoma (BCC).
- Thiazide's effect on BCC risk appears dependent on combination therapy.
- Current recommendations emphasize UV protection over altering antihypertensive regimens for BCC prevention.
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