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Updated: Jan 17, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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Reversing Lanmodulin's Metal-Binding Sequence in Short Peptides Surprisingly Increases the Lanthanide Affinity.

Sophie M Gutenthaler-Tietze1,2, Jerome Kretzschmar3, Satoru Tsushima3,4

  • 1Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, München, Germany.

Angewandte Chemie (International Ed. in English)
|September 23, 2025
PubMed
Summary

Reversing natural lanthanide-binding protein sequences boosted peptide affinity for rare earth elements (REEs) by tenfold. This breakthrough advances REE recycling and bio-inspired separation technologies.

Keywords:
CDEF‐hand peptidesFluorescenceITCLanmodulinLanthanidesNMR

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