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Updated: May 4, 2026
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
Tetrahydroxy Diboron-Initiated Injectable Hydrogel with Integrated Rapid Gelation, Fatigue Resistance, Bioadhesion,
Peiyue Pan1, Qianqian Liang2, Jia Xu3
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
None:
Injectable hydrogels are promising for periodontitis treatment, yet achieving rapid gelation, mechanical strength, and multifunctionality under physiological conditions is challenging. Here, we report a tetrahydroxy diboron (THDB)-initiated hydrogel comprising N,N-dimethylacrylamide (DMAA), chlorhexidine, and carboxymethyl chitosan (CMCS), which gels within 2 min without deoxygenation. THDB reacts with vinyl monomers and oxygen to overcome inhibition while undergoing structural evolution to form functional domains. The hydrogel features: (1) dynamic hydrogen bonding and B-O/N coordination for enhanced strength; (2) THDB-CMCS interaction for strong bioadhesion; (3) boronic acid-induced acidity for antibacterial activity against P. gingivalis, S. mutans, S. aureus, and E. coli; and (4) reactive oxygen species (ROS) scavenging via residual B-B bonds to promote osteogenesis. In vivo, it accelerates alveolar bone regeneration in a rat periodontitis model. This one-step injectable platform integrates gelation, reinforcement, adhesion, antibacterial, and antioxidative properties, offering strong therapeutic potential for periodontitis and related inflammatory diseases.
