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Updated: Jan 17, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis

Xue Wang1,2, Jiahua Luo1, Lifeng Han3

  • 1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Hepatology (Baltimore, Md.)
|September 23, 2025
PubMed
Summary

MYC oncogene dysregulation drives liver cancer. SF3B3 regulates Farnesoid X receptor (FXR) splicing, impacting MYC-driven hepatocarcinogenesis and offering potential therapeutic targets for hepatocellular carcinoma (HCC).

Keywords:
MYCbile acidfarnesoid X receptorhepatocellular carcinoma

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