Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-PSMA hormone-sensitive prostate cancer: a distinct clinical and molecular state.

Molecular medicine (Cambridge, Mass.)·2026

Same author

Troxerutin mitigates ferroptosis-related neuroinflammation by regulating the microglial NOX4/Nrf2 axis in Parkinson's disease.

Free radical biology & medicine·2026

Same author

Three large language models demonstrate competitive performance in Traditional Chinese Medicine national medical licensing examinations over two years.

Scientific reports·2026

Same author

FcγRIIb deficiency inhibits tumor development by attenuating the immunosuppressive phenotype of MDSCs.

Immunology letters·2026

Same author

Spatiotemporally engineered tumor-derived extracellular vesicle-based scaffold vaccine for personalized cancer immunotherapy.

Nature communications·2026

Same author

Aptamer-Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Detection and cross-organ characterization of physiological response to microplastic stress in Panax ginseng based on hyperspectral imaging assisted with machine learning.

Talanta·2026

Same journal

Electron-driven proton transfer behaviors in oxidative DNA lesion 8-oxoguanine: A computational study.

Talanta·2026

Same journal

TiO<sub>2</sub> nanoengineering for high-performance photoelectrochemical biosensors: From fundamental strategies to frontier applications.

Talanta·2026

Same journal

CRISPR-based diagnostics for ESKAPE drug-resistant bacteria: From proof-of-concept to point-of-care.

Talanta·2026

Same journal

Integrated 3D printed wearable microfluidics with removable electrochemical sensor for morphine monitoring in sweat.

Talanta·2026

Same journal

Eu-doped Tourmaline@MOF-ZnO core-shell nanocomposites: Enabling UV-activated room-temperature and ppb-level n-butanol sensing.

Talanta·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 17, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Surface-enhanced Raman spectroscopy for exosome profiling: methodology and application.

Yang Cheng¹, Jiayi Wang¹, Qihan Zhang¹

¹Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China.

|September 23, 2025

Summary

This summary is machine-generated.

Surface-enhanced Raman spectroscopy (SERS) offers powerful methods for analyzing exosomes, which are crucial biomarkers. This review explores SERS applications in exosome fingerprinting and biomarker profiling for disease diagnosis and origin tracing.

Keywords:

Exosomal biomarker profiling Exosome fingerprinting Exosomes Liquid biopsy Surface-enhanced Raman spectroscopy (SERS)

More Related Videos

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jan 17, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Area of Science:

Biotechnology
Spectroscopy
Nanotechnology

Background:

Exosomes are nanoscale vesicles carrying cellular cargo, valuable for liquid biopsy due to their origin-specific characteristics.
Exosome profiling is essential for biomarker discovery and disease diagnosis.

Purpose of the Study:

To review current methodologies and applications of surface-enhanced Raman spectroscopy (SERS) for exosome profiling.
To highlight SERS-based exosome fingerprinting and biomarker profiling strategies.

Main Methods:

Categorization of SERS substrates for exosome fingerprinting.
Emphasis on tailored strategies for exosome analysis.
Review of label-free SERS methods for biomarker discovery.

Main Results:

SERS enables exosome origin tracing and disease diagnosis through fingerprinting.
Detection of exosomal proteins and nucleic acids using SERS.
Advancements in label-free SERS for biomarker discovery.

Conclusions:

SERS is a promising technique for comprehensive exosome profiling.
Further development is needed to address challenges and expand SERS applications in liquid biopsy and diagnostics.