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Published on: July 10, 2018
Tetramethylpyrazine modulates airway inflammation and remodeling in bronchial asthma: A review
Zichao Han1, Fei Yu1, Zhen Ding1
1Zibo Traditional Chinese Medicine Hospital, Zibo 255300, Shandong, China.
Abstract:
Bronchial Asthma, characterized by chronic airway inflammation and remodeling, poses significant clinical challenges. Long-term use of conventional therapies often leads to metabolic complications and drug resistance. The bioactive alkaloid Tetramethylpyrazine, derived from Ligusticum chuanxiong Hort. (Apiaceae), demonstrates multi-target therapeutic potential through pathway modulation. TMP restores Th1/Th2 and Th17/Treg immune balance via Gαs/cAMP/PKA and AMPK/NF-κB signaling while suppressing ORMDL3-mediated collagen deposition. Clinical evidence demonstrates effective symptom alleviation with minimal adverse effects, establishing TMP as a promising complementary strategy for asthma management.
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