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Non-coding RNA methylation modifications in ovarian cancer

Siyun Deng1, Ziyi Guo1, Shaojia Wang2

  • 1Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, 381 Nanchen Road, Shanghai 200444, China.

Pathology, Research and Practice
|September 23, 2025
PubMed

Insights

RNA methylation, a key process in gene regulation, is increasingly linked to ovarian cancer (OC) development. This review explores how methylated non-coding RNAs (ncRNAs) influence OC progression and treatment resistance.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Ovarian cancer (OC) is a heterogeneous gynecological malignancy with high mortality.
  • Non-coding RNAs (ncRNAs) regulate gene expression and protein function.
  • RNA methylation (m6A, m1A, m5C, m7G) is a crucial post-transcriptional modification involved in various biological processes and cancer development.

Purpose of the Study:

  • To review common RNA methylation modifications and their associated enzymes.
  • To summarize methylated ncRNAs implicated in ovarian cancer regulation.
  • To explore the mechanisms of ncRNA methylation in OC occurrence, proliferation, immune response, and drug resistance.

Main Methods:

  • Literature review of scholarly inquiries on RNA methylation and ovarian cancer.
  • Summary of four common RNA methylation types and their enzymes.
  • Analysis of current reports on ncRNA methylation's role in OC.

Main Results:

  • Methylation alterations in ncRNAs are implicated in the etiology of ovarian cancer.
  • ncRNA methylation influences OC occurrence, proliferation, immune response, and drug resistance.
  • Specific methylation-related long non-coding RNAs (lncRNAs) show potential for further study.

Conclusions:

  • RNA methylation, particularly in ncRNAs, plays a significant role in ovarian cancer pathogenesis.
  • Understanding ncRNA methylation mechanisms offers insights into OC development and treatment.
  • Methylation-related lncRNAs represent promising targets for future research and therapeutic strategies in ovarian cancer.
Keywords:
Non-coding RNAOvarian cancerRNA methylation

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