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Published on: August 7, 2017
Analysis of Predictive Factors for Mycoplasma-associated Plastic Bronchitis in Children
Fengzhi Jiang1, Xinlong Zhou1, Huifang Zhang1
1Dongguan Maternal and Child Health Care Hospital, Department of Pediatrics, Dongguan, Guangdong, 523006, China.
Objective:
In recent years, the prevalence of Mycoplasma pneumoniae infection has led to complications such as mycoplasma-associated plastic bronchitis (M-PB) in some children. Therefore, it is particularly important to identify the predictive factors of M-PB occurrence and make early diagnosis and treatment.
Method:
Analyze the pathogen of PB and collect 32 cases of M-PB and 60 cases of non-morphological mycoplasma pneumonia (N-PB) for comparative analysis.
Result:
(1) A total of 126 cases of plastic bronchitis (PB) were collected, and the main pathogens were as follows: among them, 112 cases were combined with mycoplasma infection, 16 cases were combined with rhinovirus, 15 cases were combined with Streptococcus pneumoniae and Haemophilus influenzae respectively, 10 cases were combined with adenovirus, 5 cases were combined with bocavirus, 5 cases were combined with Moraxella catarrhalis, 3 cases were combined with Staphylococcus aureus, and 3 cases were combined with influenza A and B viruses respectively. (2) Binary Logistic regression analysis showed that the duration of fever and the ratio of neutrophils to lymphocytes (NLR) in blood were independent predictors of M-PB occurrence. The duration of fever (OR 1.525, 95% confidence interval: 1.112-2.089, P = 0.009), and NLR (OR 1.738, 95% confidence interval: 1.121-2.694, P = 0.013) (as shown in Table 3).
Conclusion:
The main pathogen of plastic bronchitis is mycoplasma, and most of them are resistant to macrolide antibiotics. Other pathogens include rhinovirus, Streptococcus pneumoniae, Haemophilus influenzae and adenovirus. The duration of fever and NLR are independent predictive factors for the occurrence of mycoplasma-related plastic bronchitis.
Insights
Mycoplasma pneumoniae is a key cause of plastic bronchitis in children. Longer fever duration and higher neutrophil-to-lymphocyte ratio (NLR) predict this serious condition, aiding early diagnosis.
Area of Science:
- Pediatric Infectious Diseases
- Respiratory Medicine
- Microbiology
Background:
- Mycoplasma pneumoniae infections can lead to complications like mycoplasma-associated plastic bronchitis (M-PB) in children.
- Early identification of predictive factors for M-PB is crucial for timely diagnosis and treatment.
Purpose of the Study:
- To identify predictive factors for the occurrence of M-PB.
- To analyze pathogens associated with plastic bronchitis (PB).
Main Methods:
- Comparative analysis of 32 M-PB cases and 60 non-mycoplasma-associated plastic bronchitis (N-PB) cases.
- Pathogen identification in 126 PB cases.
- Binary Logistic regression analysis to determine independent predictors.
Main Results:
- Mycoplasma infection was present in 112 of 126 PB cases; other pathogens included rhinovirus, Streptococcus pneumoniae, and Haemophilus influenzae.
- Longer fever duration (OR 1.525) and elevated neutrophil-to-lymphocyte ratio (NLR) (OR 1.738) were identified as independent predictors of M-PB.
- Many Mycoplasma infections were resistant to macrolide antibiotics.
Conclusions:
- Mycoplasma is the primary pathogen in PB, often resistant to macrolides.
- Fever duration and NLR are significant independent predictive factors for M-PB.
- These findings support early diagnosis and targeted treatment strategies for M-PB.
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