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Updated: Jan 17, 2026
04:32
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
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Ventilator-associated pneumonia biomarker evaluation (VIBE) study: protocol for a prospective, observational,
Owen Albin1, Sudha Nadimidla2, Louis Saravolatz3
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA oalbin@med.umich.edu.
BMJ Open
|September 23, 2025
Summary
The VIBE study seeks novel biomarkers for personalized ventilator-associated pneumonia (VAP) treatment. Identifying a dynamic alveolar biomarker signature could guide tailored antibiotic durations, improving patient outcomes and reducing resistance.
Area of Science:
- Critical care medicine
- Infectious diseases
- Biomarker discovery
Background:
- Current ventilator-associated pneumonia (VAP) treatment guidelines use standardized antibiotic durations, neglecting individual patient factors and increasing risks of antimicrobial resistance and treatment failure.
- A need exists for VAP-specific biomarkers to enable personalized treatment strategies and optimize patient care.
- The Ventilator-associated Pneumonia Biomarker Evaluation (VIBE) study was initiated to address this gap.
Purpose of the Study:
- To identify a dynamic alveolar biomarker signature associated with treatment response in VAP patients.
- To inform personalized antibiotic duration strategies in future clinical trials for VAP management.
- To develop a predictive model for VAP treatment failure based on temporal biomarker changes.
Main Methods:
- Prospective, observational, case-cohort study involving 125 adult VAP patients in intensive care units.
- Collection of bronchoalveolar lavage samples on Days 1, 3, and 5 post-VAP diagnosis for biomarker assessment.
- Assessment of quantitative respiratory culture bioburden, alveolar neutrophil percentage, and pathogen genomic load; expert panel adjudication of treatment outcomes.
Main Results:
- Comparison of absolute and mean-fold changes in alveolar biomarker levels between VAP clinical cure and treatment failure groups.
- Derivation of a composite temporal alveolar biomarker signature predictive of VAP treatment failure.
- Data analysis focused on identifying key biomarkers and their dynamic changes indicative of treatment response.
Conclusions:
- The VIBE study aims to establish a novel biomarker signature for personalized VAP treatment.
- Findings will support the development of tailored antibiotic duration strategies, potentially improving clinical outcomes.
- This research contributes to optimizing VAP management and combating antimicrobial resistance.
Keywords:
Adult intensive & critical careEpidemiologyMolecular diagnosticsRespiratory infectionsThoracic medicineMore Related Videos
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