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FET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners

Malin Lindén1, Lisa Andersson1, Heba Albatrok1

  • 1Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Cellular & Molecular Biology Letters
|September 23, 2025
PubMed
Summary

FET oncoproteins interact with SWI/SNF complexes in sarcomas, influencing their composition and function. These interactions, along with epigenetic changes, contribute to specific tumor types in FET sarcoma.

Keywords:
Ewing sarcomaFET fusion oncoproteinsMyxoid liposarcomaQuantitative mass spectrometrySWI/SNF chromatin remodeling complex

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