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Monoamine Oxidase B Expression is a Prognostic Factor in Patients With Colorectal Cancer
Jiyoon Jung1, Jeong Won Kim1, Joo Young Kim2
1Department of Pathology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine.
Applied Immunohistochemistry & Molecular Morphology : AIMM
|September 24, 2025
Summary
High expression of Monoamine Oxidase B (MAOB) in colorectal cancer patients correlates with aggressive tumor behavior and poorer survival. MAOB may serve as a significant prognostic marker for colorectal cancer.
Area of Science:
- Oncology
- Biochemistry
- Molecular Biology
Background:
- Monoamine oxidases (MAOs) generate reactive oxygen species, and their expression impacts tumor prognosis.
- MAO involvement in cancer progression necessitates understanding their role in colorectal cancer (CRC).
Purpose of the Study:
- To investigate the expression of Monoamine Oxidase A (MAOA) and Monoamine Oxidase B (MAOB) in colorectal cancer (CRC).
- To assess the clinicopathologic significance and prognostic value of MAOA and MAOB expression in CRC patients.
Main Methods:
- Immunohistochemistry was employed to evaluate MAOA and MAOB expression levels.
- Statistical analyses were performed to correlate expression with clinicopathologic factors and patient survival.
Main Results:
- High MAOB expression was linked to poor tumor differentiation, advanced tumor stage, metastasis, and higher MAOA expression.
- Patients with high MAOB expression exhibited significantly worse overall survival (HR=2.974, P<0.001).
- MAOB was identified as an independent poor prognostic factor in CRC (HR=1.680, P=0.044).
Conclusions:
- Elevated MAOB expression is associated with aggressive clinicopathologic features in colorectal cancer.
- MAOB may represent a valuable prognostic biomarker for predicting outcomes in CRC patients.
