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Updated: Jan 17, 2026
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
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Clofarabine monotherapy in refractory multisystem LCH with gastrointestinal involvement
Stephanie Aronson1, Vivian Tang2, Klaudia Cios1
1Department of Pediatrics, Maimonides Children's Hospital, Brooklyn, New York, USA.
Pediatric Hematology and Oncology
|September 24, 2025
Summary
Gastrointestinal Langerhans Cell Histiocytosis (LCH) can be resistant to standard treatments. Clofarabine shows promise as an effective second-line therapy for refractory GI-LCH cases, suggesting a need for revised risk stratification.
Area of Science:
- Pediatric Oncology
- Histiocytic Disorders
- Gastrointestinal Pathology
Background:
- Langerhans Cell Histiocytosis (LCH) is a rare multisystemic histiocytic disorder.
- Gastrointestinal (GI) tract involvement in LCH presents unique challenges and can be refractory to conventional therapies.
- Early recognition and effective treatment strategies for GI-LCH are critical for patient outcomes.
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