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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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ABO Incompatible Kidney Transplantation in Indian Children.

Jitendra Meena1, Aditi Sinha1, Menka Yadav1

  • 1Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Pediatric Transplantation
|September 24, 2025
PubMed
Summary
This summary is machine-generated.

ABO incompatible (ABOi) kidney transplants in children are feasible in India, showing similar graft survival and patient outcomes compared to ABO compatible (ABOc) transplants. This approach expands the donor pool for pediatric kidney recipients.

Keywords:
graft survivalimmunoadsorptionkidney transplantation

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Pediatric surgery

Background:

  • Kidney transplantation in developing nations relies heavily on live donors, leading to extended waiting lists for patients lacking ABO compatible (ABOc) donors.
  • ABO incompatible (ABOi) kidney transplantation offers a viable strategy to broaden the donor pool.
  • This study details the center's experience with pediatric ABOi kidney transplantation.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of ABO incompatible (ABOi) kidney transplantation in children.
  • To compare the results of ABOi kidney transplantation with ABO compatible (ABOc) transplantation in a pediatric cohort.
  • To assess graft survival, patient survival, and renal function post-transplantation.

Main Methods:

  • A retrospective analysis of medical records for pediatric kidney transplantations (ABOi and ABOc) performed between January 2019 and December 2023.
  • Desensitization protocols for ABOi recipients included rituximab, immunoadsorption or plasma exchange, and IVIg.
  • Induction therapy utilized basiliximab or ATG, followed by maintenance immunosuppression with tacrolimus, mycophenolate mofetil, and prednisolone.

Main Results:

  • Seven ABOi and 46 ABOc kidney transplantations were performed over five years, with comparable patient and donor characteristics.
  • Rejection-free graft survival rates were similar between the ABOi and ABOc groups (p=0.88).
  • Median estimated glomerular filtration rate (eGFR) at last follow-up was comparable (61.4 ml/min/1.73 m² in ABOi vs. 50.9 ml/min/1.73 m² in ABOc; p=0.23), with similar patient and graft survival rates.

Conclusions:

  • Pediatric ABO incompatible kidney transplantation in India is a feasible procedure.
  • The outcomes, including graft survival and renal function, are satisfactory and comparable to ABO compatible transplants.
  • ABOi transplantation effectively expands donor options for children requiring kidney transplants.