Personalization of therapy for patients with eosinophilic esophagitis

The rising global prevalence of eosinophilic esophagitis (EoE) has made it a major topic of interest in both Clinical Immunology and Gastroenterology. Despite advances in understanding its physiopathology, optimal long-term management remains challenging due to disease heterogeneity and variable treatment responses. An integrated, patient-centered approach can be valuable in clinical practice, improving outcomes by tailoring treatment strategies to individual patient needs.

This review explores the current therapeutic options of EoE, including proton pump inhibitors (PPIs), topical corticosteroids, elimination diets, and biologic agents, focusing on treatment efficacy, limitations, and patient-centered factors such as quality of life, treatment adherence, and comorbid atopic conditions. The article also examines recent guidelines and the rationale behind personalized therapy approaches. A comprehensive review of the current literature on personalized therapy for EoE has been conducted, highlighting recent developments in treatment strategies and individualized patient care approaches.

There is no one-size-fits-all therapeutic strategy for EoE. Given the complexity of patient profiles, including immunologic phenotypes, psychological attitudes, and socioeconomic factors, therapeutic choices must be personalized. Shared decision-making is essential to align treatment plans with patient values and improve both clinical outcomes and long-term adherence.