Digital Vater-Pacini Corpuscles Neuroma: Where Does it Come from?

Until now, we were able to find 38 reports of Vater-Pacini corpuscles (VPC) neuromas of the digital nerve. We reported our first case in 2023. In this article, we present our subsequent three cases of VPC neuromas and discuss their clinical presentations and anatomical origin. Interestingly, the hyperplastic VPC neuromas were found within the epineurium of the digital nerve in two cases. Anatomically, the VPCs extend, like a kite on a string, from the digital nerve and should not exist within the peripheral nerve. The regeneration and remodelling of VPCs over time have been entirely unknown. There may be stem tissue, like seeds of VPCs, in the peripheral nerves. When they receive some stimulation, they may form new VPCs. Moreover, with hyperstimulation, they may excessively form and become a VPC neuroma. Level of Evidence: Level V (Therapeutic).