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The Efficiency of Plant Extracts in the Prevention of Gastric Cancer: A Systematic Review

Mahsa Rezvan1, Seyed Erfan Hossini2, Kimia Sarmast3

  • 1TUM School of Medicine and Health, Institute of Pathology Technical University of Munich Munich Germany.

Health Science Reports
|September 24, 2025
PubMed
Abstract

Insights

Certain plant extracts show promise for preventing gastric cancer by inhibiting tumor growth and inflammation. Further research is needed to address bioavailability and safety for clinical use.

Area of Science:

  • Phytochemistry
  • Oncology
  • Molecular Biology

Background:

  • Gastric cancer presents a significant global health challenge, characterized by high rates of illness and death.
  • Investigating natural compounds offers a promising avenue for developing novel chemopreventive strategies against gastric cancer.

Purpose of the Study:

  • This systematic review aims to evaluate the potential of various plant extracts in preventing gastric cancer.
  • The study analyzes the underlying bioactive mechanisms of these plant extracts.

Main Methods:

  • A comprehensive analysis of 62 studies, encompassing in vitro, in vivo, and clinical trial data.
  • Evaluation focused on the antiproliferative, proapoptotic, antiangiogenic, and anti-inflammatory effects of plant extracts.

Main Results:

  • Several plant extracts, including *Marsdenia tenacissima*, *Curcuma longa*, and *Rhus verniciflua*, demonstrated significant potential in preclinical and clinical investigations.
  • These extracts exhibit promising anticancer properties through modulation of key cellular pathways.

Conclusions:

  • Plant-derived compounds show considerable promise for gastric cancer prevention.
  • Further research is essential to overcome challenges related to bioavailability, standardized dosing, and long-term safety before clinical application.
Keywords:
bioavailabilitychemopreventiongastric cancerpharmacokineticsplant extracts

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