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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Blinding01:11

Blinding

3.8K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 17, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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The Duke Baerveldt 350 Versus Ahmed ClearPath 350 Study (DBACS): A Randomized Control Trial In Adults With Medically

Michael S Quist1, Andrew W Gross1, Nicholas A Johnson1

  • 1Duke University Eye Center, Duke University, Durham, NC, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|September 24, 2025
PubMed
Summary

The Ahmed ClearPath (ACP) demonstrated superior efficacy over the Baerveldt 350 (BVT) for glaucoma drainage, achieving lower intraocular pressure (IOP). Both devices showed comparable safety profiles in this comparative study.

Area of Science:

  • Ophthalmology
  • Glaucoma Management
  • Surgical Devices

Background:

  • Glaucoma drainage devices (GDDs) are crucial for managing medically refractory glaucoma.
Keywords:
glaucoma drainage deviceglaucoma surgerytube shunt

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  • Non-valved GDDs offer a surgical option to reduce intraocular pressure (IOP).
  • Comparing the efficacy and safety of different GDDs is essential for clinical decision-making.