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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Bioinspired reconfigurable cloverleaf DNA origami as a versatile platform for visual molecular detection.

Si Sun1,2, Xi Shu1, Xin Chen1

  • 1Institute of Computing Science and Technology, Guangzhou University Guangzhou 510006 People's Republic of China.

RSC Advances
|September 24, 2025
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Summary

This study introduces a dynamic DNA origami system that mimics natural processes for reconfigurable nanostructures. The bioinspired design allows for programmable molecular detection and self-assembly of complex nanoscale architectures.

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Area of Science:

  • Nanotechnology
  • Biomimetic Engineering
  • Molecular Biology

Background:

  • DNA origami has advanced from static to dynamic nanostructures.
  • Programmable systems are crucial for sophisticated nanofabrication.
  • Bioinspired designs offer novel functionalities in nanotechnology.

Purpose of the Study:

  • To develop a bioinspired cloverleaf DNA origami system.
  • To enable structural reconfiguration, molecular detection, and higher-order assembly.
  • To integrate biomimetic nanomechanics with visual molecular detection.

Main Methods:

  • Design of two DNA origami structures: flexible Leaf4 and stable Lucky4.
  • Characterization using atomic force microscopy (AFM) and simulations (tacoxDNA, CanDo).
  • Demonstration of topology transition via strand replacement and molecular sensing via split capture strands.

Main Results:

  • Leaf4 demonstrated a water lily-like closure via apex strand replacement.
  • Lucky4 functioned as a sensing platform, detecting target sequences via AFM.
  • Two Lucky4 units assembled into taller sandwich structures upon target binding.

Conclusions:

  • The cloverleaf DNA origami system exhibits biomimetic nanomechanics and structural reconfiguration.
  • The system enables reversible molecular detection and programmable assembly.
  • This work advances dynamic DNA origami for complex nanoscale applications.