Related Experiment Video
Updated: Jan 17, 2026
09:37
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
10.3K
The structure and function of FBXW5 in human diseases
Yuyang Han1, Tao Yu1, Zhaowu Ma1
1School of Basic Medicine, Yangtze University, Health Science Center, Jingzhou, China.
Biochemistry and Biophysics Reports
|September 24, 2025
Summary
FBXW5, a key F-box protein in the SCF complex, is crucial for ubiquitin-mediated proteolysis. Understanding its structure and function offers therapeutic potential for diseases like cancer and neurological disorders.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- FBXW5 is an F-box protein integral to SCF complexes, mediating ubiquitin-proteolysis.
- Its role in cellular processes and disease pathogenesis is increasingly recognized.
- FBXW5 presents a potential therapeutic target for various human diseases.
Purpose of the Study:
- To provide a comprehensive overview of FBXW5 structure and function.
- To focus on FBXW5 binding motifs involved in gene regulation, recruitment, and recognition.
- To summarize the biological significance of FBXW5 in diseases and discuss future research directions.
Main Methods:
- Literature review of studies on FBXW5.
- Analysis of FBXW5's role in ubiquitin-mediated proteolysis.
- Examination of FBXW5's involvement in gene regulation and disease.
Main Results:
- FBXW5 plays a pivotal role in cellular processes via the SCF complex.
- Its binding motifs are critical for gene regulation, recruitment, and recognition.
- FBXW5 is implicated in cancers, neurological disorders, and other pathological conditions.
Conclusions:
- FBXW5 is biologically significant across diverse diseases.
- Therapeutic strategies may involve SCF inhibition or targeting downstream signaling nodes.
- Further research is essential to fully elucidate FBXW5's functions and therapeutic potential.
Related Concept Videos
01:33Pleiotropy
43.2K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.2K
01:57Protein Complexes with Interchangeable Parts
2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
02:54Canonical Wnt Signaling Pathway
10.4K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.4K
01:23Cystic Fibrosis: Pathogenesis
722
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
722
01:11Fibril-associated Collagen
3.2K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.2K
01:41Non-Canonical Wnt Signaling Pathways
8.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.3K