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The structure and function of FBXW5 in human diseases

Yuyang Han1, Tao Yu1, Zhaowu Ma1

  • 1School of Basic Medicine, Yangtze University, Health Science Center, Jingzhou, China.

Biochemistry and Biophysics Reports
|September 24, 2025
PubMed

Insights

FBXW5, a key F-box protein in the SCF complex, is crucial for ubiquitin-mediated proteolysis. Understanding its structure and function offers therapeutic potential for diseases like cancer and neurological disorders.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • FBXW5 is an F-box protein integral to SCF complexes, mediating ubiquitin-proteolysis.
  • Its role in cellular processes and disease pathogenesis is increasingly recognized.
  • FBXW5 presents a potential therapeutic target for various human diseases.

Purpose of the Study:

  • To provide a comprehensive overview of FBXW5 structure and function.
  • To focus on FBXW5 binding motifs involved in gene regulation, recruitment, and recognition.
  • To summarize the biological significance of FBXW5 in diseases and discuss future research directions.

Main Methods:

  • Literature review of studies on FBXW5.
  • Analysis of FBXW5's role in ubiquitin-mediated proteolysis.
  • Examination of FBXW5's involvement in gene regulation and disease.

Main Results:

  • FBXW5 plays a pivotal role in cellular processes via the SCF complex.
  • Its binding motifs are critical for gene regulation, recruitment, and recognition.
  • FBXW5 is implicated in cancers, neurological disorders, and other pathological conditions.

Conclusions:

  • FBXW5 is biologically significant across diverse diseases.
  • Therapeutic strategies may involve SCF inhibition or targeting downstream signaling nodes.
  • Further research is essential to fully elucidate FBXW5's functions and therapeutic potential.
Keywords:
CancerF-box proteinFBXW5Neurological diseasesRecruitment and cognitionTherapeutic targetingUbiquitin-mediated proteolysis

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