"Sneaky Spleen": Three Cases of Ectopic Splenic Tissue Mimicking Neoplasia

Emily W Gripp1, Stacey M Gargano2

  • 1Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Case Reports in Pathology
|September 24, 2025
PubMed

Ectopic splenic tissue may arise as either a congenital anomaly or acquired seeding of fragments from a mechanically disrupted spleen. Regardless of the etiology, splenic tissue presenting at unexpected sites may lead to symptomatic or incidentally discovered lesions that may raise clinical suspicion for neoplasia. We present three cases of ectopic splenic tissue that were clinically ominous and necessitated pathologic tissue examination for definitive diagnosis.