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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Related Experiment Video

Updated: Jan 17, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

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Complex Wound Reconstruction in a Patient With Ehlers-Danlos Syndrome.

Sohayla Rostami1, Tomer Lagziel1,2, Stephanie Lynne Martinez1

  • 1From the Department of Plastic and Reconstructive Surgery, Johns Hopkins University Medical Center, Burn Unit, Bayview Campus, Baltimore, MD.

Plastic and Reconstructive Surgery. Global Open
|September 24, 2025
PubMed
Summary

Ehlers-Danlos syndrome (EDS) patients with difficult wounds may benefit from a new treatment. A split-thickness skin graft combined with the Recell device successfully healed a knee wound in an EDS patient.

Area of Science:

  • Orthopedics
  • Dermatology
  • Genetics

Background:

  • Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by collagen defects.

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  • Tissue fragility and compromised wound healing are significant challenges for individuals with EDS.
  • A patient with classical EDS experienced severe wound healing difficulties after a patellar tendon rupture.