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Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges
Sandro Carrara1, Nicolas Widmer2,3,4, Francesca Rodino1
1Bio/CMOS Interfaces Laboratory, École Polytechnique Fédérale de Lausanne (EPFL), Neuchâtel, Switzerland.
Emerging point-of-care (POC) devices offer rapid drug concentration measurements, enhancing therapeutic drug monitoring (TDM). Integration with AI and digital tools promises wider accessibility to precision medicine.
Area of Science:
- Clinical Chemistry
- Biotechnology
- Pharmacology
Background:
- Re-evaluates therapeutic drug monitoring (TDM) by comparing laboratory capabilities with emerging point-of-care (POC) devices.
- Highlights the increasing utilization potential of POC devices in various clinical settings.
Purpose of the Study:
- To review current trends in the development of POC TDM.
- To assess the potential of POC devices in clinical practice.
Main Methods:
- Narrative review of scientific and technical literature.
- Identification of publications illustrating current trends in POC TDM development.
Main Results:
- POC devices for drug concentration measurement are nearing market availability.
- Portable sensors utilizing various technologies can provide rapid concentration measurements.
- AI and digital technologies (e.g., machine learning) are crucial for accurate drug quantification and model-informed precision dosing.
Conclusions:
- Emerging technologies show significant potential to broaden TDM applications.
- POC TDM can enhance the accessibility of precision medicine for a wider patient population.
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