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Neurobrucellosis and Multiple Sclerosis: Cause, Confounder, or Coincidence?

Burak Kocaaga1, Nermin Celik1, Ozge Kaba1

  • 1Basaksehir Cam and Sakura City Hospital, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.

Revista Da Sociedade Brasileira De Medicina Tropical
|September 24, 2025
PubMed
Summary

This case study presents a rare pediatric diagnosis of coexisting neurobrucellosis and multiple sclerosis. It highlights the diagnostic challenges in differentiating infectious from autoimmune demyelinating diseases.

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Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
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