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Updated: Jan 17, 2026

Light-Controlled Fermentations for Microbial Chemical and Protein Production
Published on: March 22, 2022
Variable Bioproduction with Euglena gracilis: A Function of Light Flux or Carbon Source, Supplements, and Time
Dominik Cholewa1, Tulsi Wormuth2
1Working Group Multiscale Bioengineering, Technical Faculty, Bielefeld University, Bielefeld, Germany. dominik.cholewa@uni-bielefeld.de.
Abstract:
Euglena gracilis is neither a plant nor an animal. It generates its energy from light and CO2 purely photoautotrophically or it assimilates a carbon source chemoheterotrophically and transforms its chloroplasts into proplastids resulting in an animal cell structure. E. gracilis is a unicellular protist with a length of about 50 μm and developed by secondary endosymbiosis. For this reason, the chloroplasts have three membranes instead of a double membrane with a positive effect on the lipid content. It has no cell wall and is therefore easily bioavailable to humans. Euglena produces large amounts of vitamin E α-tocopherol and the β-1,3-glucan paramylon in granule form and has a good amount of lipids. Thanks to its contractile vacuole, Euglena is able to grow in a wide pH range from around pH 1-11. Cultivation in the acidic range thus simplifies cultivation on a technical scale under axenic conditions and enhances the solubility of solids and trace elements.

