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[18F]THK5351 uptake in multiple system atrophy compared with other parkinsonian disorders
Yoshihiko Horimoto1,2, Emi Hayashi3, Yoshihiro Ito3
1Department of Neurology, Nagoya City Rehabilitation Center, Nagoya, Japan. holly@chojuken.net.
Background:
The pathological processes in the early stages of multiple system atrophy (MSA) are still incompletely understood. Moreover, early-stage MSA is difficult to diagnose.
Objectives:
We investigated the monoamine oxidase-B positron emission tomography findings with an aim to characterize degeneration in the early stages of MSA.
Methods:
Positron emission tomography using [18F]THK5351 was performed on three patients with relatively early stages of MSA: two with cerebellar-type MSA and one with parkinsonian-type MSA. The findings were compared with nine patients with other parkinsonian disorders (Lewy body disease, progressive supranuclear palsy, or spinocerebellar ataxia type 31) and six control subjects (Alzheimer disease or normal aging).
Results:
Uptake of [18F]THK5351 in the middle cerebellar peduncles was distinctly higher in all three patients with MSA than in patients with other parkinsonian disorders or control subjects (both p < 0.001; unpaired t-tests).
Conclusions:
The results of the presented patients suggest the potential diagnostic utility of [18F]THK5351 imaging and may help to clarify the preclinical pathology of the middle cerebellar peduncle in MSA.
Insights
Positron emission tomography using [18F]THK5351 shows higher uptake in the middle cerebellar peduncles in early multiple system atrophy (MSA). This finding may aid in diagnosing MSA and understanding its early pathology.
Area of Science:
- Neuroimaging
- Neurology
- Medical Diagnostics
Background:
- Early-stage multiple system atrophy (MSA) pathology is poorly understood.
- Diagnosing early MSA presents significant clinical challenges.
Purpose of the Study:
- To characterize early-stage multiple system atrophy (MSA) using monoamine oxidase-B positron emission tomography (PET).
- To investigate the diagnostic potential of [18F]THK5351 PET imaging in MSA.
Main Methods:
- PET imaging with [18F]THK5351 was conducted on three early-stage MSA patients.
- Findings were compared against patients with other parkinsonian disorders and healthy controls.
Main Results:
- All three MSA patients exhibited significantly higher [18F]THK5351 uptake in the middle cerebellar peduncles.
- This elevated uptake was distinct compared to other parkinsonian disorders and control groups (p < 0.001).
Conclusions:
- [18F]THK5351 PET imaging shows promise as a diagnostic tool for early MSA.
- This imaging technique may elucidate the preclinical pathology within the middle cerebellar peduncle in MSA.
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