Non-invasive convective head cooling during stroke thrombectomy: A prospective multi-center feasibility trial

Area of Science:

• Neurology
• Cardiovascular Medicine
• Medical Technology

Background:

• Non-invasive convective head cooling offers potential neuroprotection for ischemic stroke patients.
• It aims to selectively cool the ischemic penumbra, a critical area during stroke.
• Investigating its use before and during endovascular thrombectomy (EVT) is crucial.

Purpose of the Study:

• To assess the feasibility of non-invasive convective head cooling in ischemic stroke patients.
• To evaluate patient adherence and safety during EVT procedures.
• To determine the potential role of head cooling as an adjunct therapy.

Main Methods:

• A multi-center, prospective, open-label trial was conducted.
• 40 ischemic stroke patients scheduled for EVT were enrolled.
• Patients received head cooling ( -5°C to 0°C) from cap application until EVT completion.

Main Results:

• High feasibility: 97.5% of participants met the adherence endpoint (cooling for ⩾50% of the time).
• The therapy was well-tolerated with no serious adverse events attributed to head cooling.
• Successful reperfusion (eTICI 2b-3) was achieved in 95% of patients.

Conclusions:

• Non-invasive convective head cooling is a feasible neuroprotective strategy for patients undergoing EVT.
• The therapy demonstrated high adherence and a favorable safety profile.
• Further investigation in larger randomized controlled trials is recommended.